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Inflammatory response to elective percutaneous coronary intervention is related to myocardial injury

Priscilla Teixeira Céo Frisso1, Henrique Trombini Pinesi1,2, Fernando Ramos de Mattos2

  • 1Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Einstein (Sao Paulo, Brazil)
|October 15, 2025
PubMed

Insights

Percutaneous coronary intervention (PCI) increases inflammatory biomarkers in stable coronary disease patients. This heightened inflammatory response is linked to myocardial injury, suggesting a connection between inflammation and PCI complications.

Area of Science:

  • Cardiology
  • Immunology

Background:

  • Inflammation is increasingly recognized as a factor in cardiovascular disease.
  • Previous research suggests a link between inflammation and complications following percutaneous coronary intervention (PCI).

Purpose of the Study:

  • To investigate the relationship between percutaneous coronary intervention and inflammatory responses in patients with stable coronary disease.
  • To determine if the inflammatory response after PCI correlates with myocardial injury.

Main Methods:

  • Analysis of inflammatory biomarker levels in patients undergoing PCI.
  • Correlation analysis between biomarker levels and indicators of myocardial injury.

Main Results:

  • Percutaneous coronary intervention in stable coronary disease patients results in elevated levels of inflammatory biomarkers.
  • A significant correlation was observed between the inflammatory response and the extent of myocardial injury.

Conclusions:

  • Percutaneous coronary intervention triggers a measurable inflammatory response in patients with stable coronary disease.
  • The degree of myocardial injury following PCI is significantly associated with the intensity of the inflammatory response.

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