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Yu Yu Oliynyk

    Klinichna Khirurhiia
    |November 28, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Combined gastrectomy (CG) offers expanded radical treatment options for locally-spread gastric cancer (LSGC). While complications and 30-day lethality exist, CG demonstrates improved survival outcomes compared to subtotal distal gastric resection.

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    Area of Science:

    • Surgical Oncology
    • Gastroenterology
    • Clinical Research

    Background:

    • Locally-spread gastric cancer (LSGC) presents significant treatment challenges.
    • Combined gastrectomy (CG) involves extensive surgical intervention for advanced LSGC.
    • Evaluating the outcomes of CG is crucial for optimizing patient management.

    Purpose of the Study:

    • To analyze the immediate and late results of combined gastrectomy (CG) in patients with locally-spread gastric cancer (LSGC).
    • To compare the efficacy of CG with subtotal distal gastric resection.
    • To assess the feasibility and impact of combined operative interventions on radical treatment possibilities.

    Main Methods:

    • Retrospective analysis of 719 patients undergoing combined gastrectomy (CG).

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  • Inclusion of data on additional resection of adjacent organs in 165 cases.
  • Evaluation of early postoperative complications, 30-day lethality, and long-term survival rates (average, median, 3-year, and 5-year survival).

    • Main Results:

    • A total of 116 patients (16.1%) experienced early postoperative complications (77.7% surgical, 22.3% non-surgical).
    • 30-day postoperative lethality was 11.1%.
    • Average postoperative survival was 22.9 months (median 9.3 months), with 3-year and 5-year survival rates of 18.9% and 12.9%, respectively. CG showed better outcomes than subtotal distal gastric resection.

    Conclusions:

    • Combined gastrectomy (CG) is a viable option for radical treatment of locally-spread gastric cancer (LSGC), expanding therapeutic possibilities.
    • Despite noted complications and lethality, CG demonstrates acceptable survival outcomes.
    • The study supports the expediency of combined operative interventions in selected LSGC patients.