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Characterization of ulcerative colitis-associated constipation syndrome (proximal constipation)
Sally L James1, Daniel R van Langenberg1, Kirstin M Taylor2
1Eastern Health Clinical School, Monash University Box Hill Hospital Box Hill Victoria Australia.
JGH Open : an Open Access Journal of Gastroenterology and Hepatology
|November 29, 2018
Summary
Proximal constipation affects nearly half of ulcerative colitis patients, particularly women with active disease. Further research is needed to validate its definition and optimize treatment for this common condition.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Inflammatory Bowel Disease Research
Background:
- Proximal constipation in ulcerative colitis (UC) is clinically recognized but lacks formal definition, prevalence data, and understanding of treatment effects.
- This study addresses the under-described nature of constipation symptoms in UC patients.
Purpose of the Study:
- To establish a working definition for proximal constipation in UC.
- To determine the prevalence of proximal constipation in a UC cohort.
- To identify factors associated with proximal constipation and its impact on disease management.
Main Methods:
- A cross-sectional study of consecutive UC patients.
- Established a working definition for proximal constipation.
- Assessed disease activity, symptoms, and medication use via study visit and medical records.
Main Results:
- 46% of 125 UC patients met the definition of proximal constipation.
- Key symptoms included reduced stool frequency, hard stools, and abdominal pain.
- Proximal constipation was associated with female gender, left-sided UC, and active disease.
Conclusions:
- Proximal constipation is a common issue in UC, particularly in women and those with active, distal disease.
- The definition requires validation, and therapeutic strategies need evaluation.
- The term "ulcerative colitis-associated constipation syndrome" is proposed.
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