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Updated: Feb 2, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Parabens and their relation to obesity.

L Kolatorova¹, M Sramkova, J Vitku

¹Department of Steroids and Proteofactors, Institute of Endocrinology, Prague, Czech Republic. lkolatorova@endo.cz.

Physiological Research

|November 29, 2018

Summary

This study found that higher levels of methylparaben and propylparaben were present in women with obesity. Methylparaben exposure was linked to changes in hormones related to energy balance, suggesting a potential obesogenic effect.

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Area of Science:

Endocrinology
Environmental Health
Metabolic Research

Background:

Parabens are common preservatives with known endocrine-disrupting properties.
Adipose tissue exhibits endocrine activity, and chemicals can influence obesity.
Parabens are under investigation for potential obesogenic effects.

Purpose of the Study:

To explore the association between paraben exposure and obesity.
To investigate the relationship between paraben levels and key metabolic hormones.

Main Methods:

Blood plasma was collected from 27 healthy women during their menstrual cycle.
Measurements included paraben levels (methylparaben, ethylparaben, propylparaben), adipokines, and hormones regulating energy balance.
Statistical analysis, including the Kolmogorov-Smirnov test, was used to compare groups and assess associations.

Main Results:

Higher methylparaben and propylparaben levels were observed in women with a BMI of 25-34.9 compared to those with a BMI of 18.5-24.9.
Plasma methylparaben and total paraben levels positively correlated with adipsin levels.
Methylparaben showed negative associations with glucagon, leptin, and PAI-1.

Conclusions:

Methylparaben and propylparaben levels are associated with higher BMI in women.
Paraben exposure, particularly methylparaben, is linked to alterations in hormones that affect energy balance and metabolic health.
Findings suggest a potential obesogenic role for parabens, warranting further investigation.