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Related Concept Videos

Capillary Beds01:20

Capillary Beds

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Capillary beds are networks of tiny blood vessels that play a crucial role in the circulatory system. These beds are where the exchange of gases, nutrients, and waste products occurs between the blood and surrounding tissues. Each capillary bed consists of numerous capillaries, which are the smallest blood vessels in the body, typically only one cell-thick. This thinness allows for the efficient diffusion of substances.
Capillaries connect arterioles, small branches of arteries, to venules,...
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Capillary Exchange01:28

Capillary Exchange

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The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular...
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Surface Tension, Capillary Action, and Viscosity02:57

Surface Tension, Capillary Action, and Viscosity

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Surface Tension
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
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Capillaries and Their Types01:20

Capillaries and Their Types

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Capillaries, a crucial constituent of the circulatory system, are diminutive vessels with a diameter between 5–10 micrometers, accommodating perfusion to the tissues through the phenomenon known as microcirculation. Through their permeable walls, consisting of an endothelial layer ensconced by a basement membrane and sporadically dispersed smooth muscle fibers, the exchange of substances between the blood and the interstitial fluid becomes plausible. Variance in wall composition exists,...
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Capillary Electrophoresis: Instrumentation01:20

Capillary Electrophoresis: Instrumentation

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Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...
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Capillary Electrophoresis: Applications01:30

Capillary Electrophoresis: Applications

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Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
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Author Spotlight: Investigating Vascular Stiffness and Inflammation in Early Diabetic Retinopathy
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Author Spotlight: Investigating Vascular Stiffness and Inflammation in Early Diabetic Retinopathy

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RETINAL CAPILLARY MACROANEURYSMS.

Richard F Spaide1, Luis Arias Barquet2

  • 1Vitreous, Retina, Macula Consultants of New York, New York.

Retina (Philadelphia, Pa.)
|November 30, 2018
PubMed
Summary
This summary is machine-generated.

Retinal capillary macroaneurysms, large vascular lesions, were investigated. Laser photocoagulation effectively treated these rare aneurysms and associated edema.

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Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Retinal Imaging

Background:

  • Solitary large aneurysms (>200 µm) originating from retinal capillaries are uncommon.
  • Understanding their pathogenesis and treatment is crucial for retinal health.

Purpose of the Study:

  • To investigate the characteristics and clinical course of eyes with solitary large retinal capillary aneurysms.
  • To evaluate potential treatment strategies for these lesions.

Main Methods:

  • Comprehensive ophthalmologic examinations were performed on 5 patients with solitary large aneurysms.
  • Advanced imaging techniques including optical coherence tomography (OCT), OCT angiography, and fluorescein angiography were utilized.
  • Histologic evaluation was considered for understanding aneurysm wall characteristics.

Main Results:

  • Five patients (3 male) presented with solitary retinal capillary aneurysms, averaging 273.4 µm.
  • One patient with diabetic retinopathy showed aneurysm growth over time, leading to edema.
  • Laser photocoagulation successfully resolved edema and involuted the aneurysms in 4 patients.
  • Anti-VEGF treatment showed limited efficacy.

Conclusions:

  • Retinal capillary macroaneurysms are a distinct entity characterized by large, solitary aneurysms.
  • Matrix metalloproteinase-9 may play a role in the weakening of aneurysm walls.
  • Laser photocoagulation appears to be an effective treatment for associated edema and lesion involution.