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Related Concept Videos

Review and Preview01:10

Review and Preview

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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
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Review and Preview01:13

Review and Preview

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Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
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Laminins are the Adhesive Proteins of Basal Lamina00:55

Laminins are the Adhesive Proteins of Basal Lamina

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Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
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Basal Lamina are the Specialized Form of ECM01:03

Basal Lamina are the Specialized Form of ECM

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The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
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Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

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Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
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What are Cells?01:07

What are Cells?

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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
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Development of Compendium for Esophageal Squamous Cell Carcinoma
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Basal Cell Carcinoma Review.

Dennis P Kim1, Kylee J B Kus2, Emily Ruiz3

  • 1Mohs Micrographic Surgery, Brigham and Women's Faulkner Hospital, 1153 Centre Street, Suite 4J, Jamaica Plain, MA 02130-3446, USA.

Hematology/Oncology Clinics of North America
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This summary is machine-generated.

Basal cell carcinoma (BCC), the most common cancer, is rising. Understanding its causes, treatment, and prevention is key to managing this malignancy and minimizing its destructive effects.

Keywords:
BCCBasal cell carcinomaMMSMohsNMSCNonmelanoma skin cancer

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Area of Science:

  • Dermatology
  • Oncology
  • Public Health

Background:

  • Basal cell carcinoma (BCC) is the most prevalent human malignancy with increasing incidence.
  • While BCC has low mortality, it can lead to significant morbidity via local tissue destruction.
  • BCC pathogenesis involves complex interactions between environmental factors and patient-specific characteristics.

Purpose of the Study:

  • To provide a comprehensive review of Basal cell carcinoma.
  • To cover epidemiology, staging, and therapeutic options for BCC.
  • To inform appropriate treatment selection based on complications, cosmetic results, and recurrence.

Main Methods:

  • Literature review of epidemiology, staging, treatment, and prevention of BCC.
  • Synthesis of current knowledge on BCC pathogenesis.
  • Analysis of therapeutic modalities and their outcomes.

Main Results:

  • BCC incidence is rising globally.
  • Local destruction is the primary cause of morbidity.
  • Effective management requires consideration of various factors including treatment complications and recurrence rates.

Conclusions:

  • BCC management necessitates a thorough understanding of its epidemiology and pathogenesis.
  • Selection of appropriate therapeutic modalities is crucial for optimal patient outcomes.
  • Ongoing research and clinical practice should focus on effective prevention and treatment strategies for BCC.