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Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Updated: Feb 1, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Cutaneous Sarcomas.

Mehul D Bhatt¹, Vinod E Nambudiri²

¹Department of Dermatology, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

Hematology/Oncology Clinics of North America

|December 1, 2018

Summary

This summary is machine-generated.

This review covers four common cutaneous sarcomas: Kaposi sarcoma, cutaneous angiosarcoma, dermatofibrosarcoma protuberans, and cutaneous leiomyosarcoma. It details their clinical presentation, diagnosis, and treatment for these rare skin cancers.

Keywords:

Angiosarcoma Cutaneous leiomyosarcoma Cutaneous oncology Cutaneous sarcomas Dermatofibrosarcoma protuberans Kaposi sarcoma

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Cutaneous sarcomas are uncommon skin cancers with diverse clinical appearances.
Understanding these rare malignancies is crucial for timely diagnosis and effective management.

Purpose of the Study:

To provide a comprehensive overview of four prevalent types of cutaneous sarcomas.
To review the clinical, diagnostic, and therapeutic characteristics of Kaposi sarcoma, cutaneous angiosarcoma, dermatofibrosarcoma protuberans, and cutaneous leiomyosarcoma.

Main Methods:

Literature review focusing on clinical presentation.
Review of diagnostic modalities.
Summary of current therapeutic strategies.

Main Results:

Detailed descriptions of the clinical manifestations of the four selected sarcomas.
Information on histopathological and imaging diagnostic criteria.
Overview of treatment options including surgery, radiation, and systemic therapies.

Conclusions:

Accurate diagnosis and appropriate treatment of these rare skin cancers are essential.
Multidisciplinary approaches may be necessary for optimal patient outcomes.
Further research into novel therapeutic strategies is warranted.