Related Experiment Video
Updated: Feb 1, 2026

De Novo Generation of Somatic Stem Cells by YAP/TAZ
Published on: May 7, 2018
Phosphatidic Acid Enters into the YAP/TAZ Arena
Antonio Totaro1, Stefano Piccolo2
1Department of Molecular Medicine, University of Padua, Padua, Italy.
Abstract:
Reporting in Molecular Cell, Han et al. (2018;2:328-340) show that phosphatidic acid promotes YAP activity through a double-hit inhibition of the LATS kinases, suggesting a therapeutic opportunity for the treatment of YAP/TAZ-dependent cancers and opening new prospects on the connections between lipid signaling and YAP/TAZ biology.
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