Related Experiment Video
Updated: Feb 1, 2026

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
A dual-function molecularly imprinted optopolymer based on quantum dots-grafted covalent-organic frameworks for the
Dianwei Zhang1, Huilin Liu2, Weitao Geng3
1Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China; State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, 29 The Thirteenth Road, Tianjin Economy and Technology Development Area, Tianjin 300457, China.
Abstract:
Molecular imprinting is a technique for polymerization using a template molecule to produce cavities in the polymer with high selectivity. The successful synthesis of a dual-function molecularly-imprinted optopolymer (MIOP) based on quantum dots-grafted covalent-organic frameworks as adsorbents has allowed the simultaneous detection of tyramine by optosensing and solid-phase extraction coupled with high performance liquid chromatography (SPE-HPLC). The MIOP, obtained by a one-pot reverse microemulsion polymerization, selectively measured tyramine from fermented meat products. Under optimized conditions, the relative fluorescence intensity of the optosensing method increased linearly at tyramine concentrations from 35 to 35,000 µg/kg, with a detection limit of 7.0 µg/kg. For SPE-HPLC, the linear range was from 20 to 2000 µg/kg, with a detection limit of 5 µg/kg. The optosensing based on MIOP is a rapid and selective method that would be suitable for detecting TYM in food, while SPE-HPLC also provided good levels of accuracy, sensitivity, and selectivity.
Related Concept Videos
Imprinting
The Dot Product
Dot Product
In engineering, the dot product of any two vectors is the product of the magnitudes of the vectors and the cosine of the angle between them. It is denoted by a dot symbol between the two vectors.
Consider a vehicle pulling an object along the ground using a rope. If the rope makes an angle with the horizontal axis, the work done can be calculated using the dot product of the force applied and the object's displacement.
The dot...
Scalar Product (Dot Product)
The scalar product of two vectors is obtained by multiplying...
Fermentation
Fermentation is a type of metabolic process that occurs in the absence of oxygen, where organic molecules such as glucose are broken down to produce energy. During this process, the...
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

