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Related Experiment Video

Updated: Feb 1, 2026

Author Spotlight: Recent Advancements in Reoperative Foregut Surgery

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Published on: September 22, 2023

Is Conservative Surgery the Best Approach for Peripheral Calcifying Epithelial Odontogenic Tumors?

Isadora Luana Flores¹, Tissiana Rachel Rossi Schneider², Ana Carolina Uchoa Vasconcelos²

¹Department of Conservative Dentistry, Oral Pathology, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2492, Santa Cecília, Porto Alegre, RS, Brazil.

The Open Dentistry Journal

|December 4, 2018

Summary

Peripheral Calcifying Epithelial Odontogenic Tumors (CEOT) are rare oral lesions. Conservative surgery is an effective treatment for peripheral CEOT, with a low recurrence rate, even in clear cell variants.

Keywords:

Calcifying epithelial odontogenic tumor Clear cell Oral diagnosis Peripheral Surgery Treatment

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Area of Science:

Oral Pathology
Surgical Oncology

Background:

Peripheral Calcifying Epithelial Odontogenic Tumors (CEOT) are rare oral cavity neoplasms.
Clear cell variant of peripheral CEOT is exceptionally uncommon, with limited documented cases.

Purpose of the Study:

To review treatment approaches for peripheral CEOT, including the clear cell variant.
To describe a recommended treatment strategy for extraosseous CEOT.

Main Methods:

Comprehensive literature review of extraosseous CEOT case reports focusing on treatment.
Case report of a 21-year-old female diagnosed with peripheral CEOT rich in clear cells.

Main Results:

Analysis of 24 peripheral CEOT cases revealed conservative surgery as the primary treatment in 80%.
Recurrence was noted in only one case following initial conservative surgical management.

Conclusions:

The presence of clear cells in peripheral CEOT does not correlate with increased tumor aggressiveness.
Conservative surgical excision is a favorable treatment option for peripheral CEOT, yielding a low recurrence rate of approximately 4%.