Related Experiment Video
Updated: Feb 1, 2026

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
[Monoclonal gammopathy of renal significance]
Vincent Javaugue1, Céline Debiaisdelpech2, Éstelle Desport1
1Service de néphrologie, hémodialyse et transplantation rénale, CHU de Poitiers, Poitiers, France.
Abstract:
Monoclonal gammopathy of renal significance. The term "monoclonal gammopathy of renal significance" regroups all renal disorders caused by a monoclonal immunoglobulin (Ig) secreted by a nonmalignant B-cell clone. However, a small clone can synthesize a very toxic protein, producing devastating renal and sometimes systemic damages. The spectrum of renal diseases in MGRS is wide. Renal lesions are classified according to the localization, either glomerular or tubular, and to the pattern of ultrastructural organization of Ig deposits. Physico-chemical characteristics of pathogenic monoclonal Ig are probably involved in their propensity to deposit or precipitate in the kidney, as illustrated by the high rate of recurrence of renal lesions after kidney transplantation if the underlying clone is not suppressed. Early diagnosis and efficient chemotherapy are mandatory to improve renal prognosis and patient survival, particularly in patients with systemic lesions such as AL amyloidosis.
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