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Updated: Feb 1, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
[Treatment of gastroesophageal reflux disease in adults]
1Service de chirurgie digestive, Hôpital européen Georges- Pompidou, université Paris-5 René Descartes, Paris, France.
Abstract:
Treatment of gastroesophageal reflux disease in adults. The high frequency of gastroesophageal reflux disease (GERD) and the symptoms variability should lead to propose graduate treatments that have in common lifestyle modifications and postural measures. First-line drugs are antacids and it is only in case of inefficiency that in second- line anti-secretory treatment is used. This therapeutic strategy is effective in over 90% of cases. In case of treatment failure additional tests and higher doses of proton-pump inhibitor must be discussed. These treatments do not change the volume of reflux but only its wounding power. Surgical approach for laparoscopic fundoplication is discussed in case of significant anatomical abnormalities or regurgitations. Endoscopic treatment is restricted to clinical trials.
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