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Treatment of Early Vascular Ageing

C Antza1, I Doundoulakis1, M Natsis1

  • 1Hypertension Center, 3rd Department of Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Greece.

Current Pharmaceutical Design
|December 6, 2018
PubMed

Insights

Early vascular aging, characterized by accelerated arterial stiffness, can be managed through lifestyle changes and treating conditions like hypertension. This approach is key for primary cardiovascular prevention.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Gerontology

Background:

  • Artery disease is assessed using measures like ankle-brachial index and pulse wave velocity.
  • Arterial stiffness, a marker of cardiovascular disease, is linked to cardiovascular events.
  • Vascular aging refers to accelerated arterial stiffness relative to chronological age, impacting primary cardiovascular prevention.

Purpose of the Study:

  • To highlight the importance of treating early vascular aging for cardiovascular disease prevention.
  • To identify lifestyle interventions and medical conditions influencing vascular aging.
  • To suggest future research directions for vascular aging treatments.

Main Methods:

  • Review of established methods for identifying artery disease.
  • Analysis of factors influencing vascular aging progression.
  • Discussion of current treatments and future research needs.

Main Results:

  • Lifestyle interventions like exercise, moderate alcohol intake, reduced salt, and weight loss may postpone vascular aging.
  • Hypertension, diabetes, sleep apnea, and dyslipidemia accelerate vascular damage and require management.
  • Further trials are needed to optimize treatments and develop targeted therapies for vascular aging.

Conclusions:

  • Managing early vascular aging through lifestyle modifications and controlled medical conditions is crucial for primary cardiovascular prevention.
  • Targeted interventions and drug development are necessary to address the acceleration of vascular aging.
  • Further research is essential to determine optimal treatment strategies for vascular aging.

Keywords:
Atherosclerosisageingcardiovascular diseaseearly vascular aging ambulatory scoreearly vascular ageinglifestylepulse wave velocitytreatment.

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