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Updated: Feb 1, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

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Forkhead box O4 transcription factor in human neoplasms: Cannot afford to lose the novel suppressor

Chenxi Lu1, Zhi Yang2, Shuai Jiang3

  • 1Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Xi'an, China.

Journal of Cellular Physiology
|December 6, 2018
PubMed

Insights

Forkhead box O4 (FOXO4) is a key regulator in many cancers, often downregulated in tumors. Research highlights FOXO4

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Forkhead box O4 (FOXO4) is a crucial transcriptional regulator implicated in various human carcinomas.
  • Studies indicate FOXO4 downregulation correlates with increased tumorigenesis, invasiveness, and metastasis.
  • Alterations in FOXO4 are linked to patient prognosis across diverse cancer types.

Purpose of the Study:

  • To comprehensively review the clinical and pathological significance of FOXO4 in human cancer.
  • To explore the potential of future FOXO4 research in clinical applications.
  • To underscore FOXO4's potential as a therapeutic target for cancer treatment.

Main Methods:

  • Literature review of accumulated studies on FOXO4 in human cancer.
  • Analysis of clinical and pathological data related to FOXO4 expression and cancer.
  • Synthesis of current research findings on FOXO4's role in tumorigenesis and metastasis.

Main Results:

  • FOXO4 acts as an essential regulator in numerous carcinomas.
  • Downregulation of FOXO4 is a common feature in many cancers, promoting tumor progression.
  • FOXO4 status significantly impacts cancer prognosis and patient outcomes.

Conclusions:

  • FOXO4 plays a critical role in cancer development and progression.
  • Understanding FOXO4's clinical and pathological significance is vital for cancer research.
  • FOXO4 presents a promising therapeutic target for novel cancer treatments.
Keywords:
FOXO4cancerclinical applicationprogression

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