Related Experiment Video
Updated: Feb 1, 2026

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
[CLINICAL FEATURES OF ENDOMETRIOSIS IN WOMEN IN PERIMENOPAUSE].
N Zakharenko1, N Kovalenko1, I Manoliak1
1Institute of Pediatrics, Obstetrics and Gynecology named E.M. Lukyanova of the NAS of Ukraine, Department of Endocrine Gynecology; State Clinical Hospital N9, Department of Gynecology, Kiev, Ukraine.
Perimenopausal endometriosis symptoms like heavy periods and pain lessen with menopause onset. However, psycho-emotional disorders become the primary concern for women with endometriosis during perimenopause.
Area of Science:
- Gynecology
- Reproductive Medicine
- Menopause Studies
Background:
- Endometriosis is a chronic condition affecting women of reproductive age.
- Perimenopause is a transitional phase characterized by hormonal fluctuations.
- The interplay between endometriosis and perimenopause requires further investigation.
Purpose of the Study:
- To assess the clinical features of endometriosis in women experiencing perimenopause.
- To compare symptom presentation in perimenopausal women with and without endometriosis.
- To identify the leading complaints and manifestations of endometriosis during the menopausal transition.
Main Methods:
- A comparative study involving 106 women with endometriosis and climacteric syndrome, 64 women with endometriosis without climacteric syndrome, and 70 controls.
- Analysis of leading complaints, menstrual function, and pain severity.
- Patient age range: 39-55 years.
Main Results:
- Endometriosis manifestations, including hyperpolymenorrhea and pain, tend to decrease with the onset of the climacteric syndrome.
- Psycho-emotional disorders emerge as the predominant issue for women with endometriosis in perimenopause.
- Significant differences in symptom profiles were observed between groups.
Conclusions:
- The clinical presentation of endometriosis evolves during perimenopause, with a shift towards psycho-emotional symptoms.
- Early identification and management of psycho-emotional disturbances are crucial for perimenopausal women with endometriosis.
- Further research is warranted to understand the long-term impact and optimal treatment strategies.
More Related Videos
08:02Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
Published on: January 6, 2012
07:20Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
Published on: December 21, 2012
Related Concept Videos
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Endocarditis II: Clinical Features of Infective Endocarditis
Pericarditis II: Clinical Features and Diagnostic Tests
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
Myocarditis II: Clinical Features and Diagnostic Tests