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Updated: Feb 1, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
CLINICAL-PATHOGENETICAL ROLE OF DYNAMICS OF CONCENTRATION OF INTERLEUKIN-6 DEPENDING ON POLYMORPHISM OF ITS GENE IN
K Kalashnyk1, Yu Riabokon1, O Riabokon1
1Zaporizhzhya State Medical University, Ukraine.
Abstract:
The study included 83 patients with CHC who received antiviral therapy according to the EASL 2016 recommendations on a 12-week peg-IFN+SOF+RBV schedule. The aim of the study was to determine the role of IL-6 concentration dynamics in relation to the polymorphism of the gene that encodes it, in achieving a SVR during therapy. Based on the results of the study, it was established that the polymorphism of the IL-6 gene (rs1800795) in patients with CHC influenced the dynamics of IL-6 concentration and the effectiveness of AVT. In patients with CHC, the genotype CC of the polymorphism of the IL-6 gene was associated with fluctuations in the concentration of IL-6 in the blood within the reference range, which was prognostically favorable for the formation of SVR 24 for AVT according to the peg-IFNα + SOF + RBV. With the presence of CG/GG genotypes in patients with CHC, the efficacy of this treatment was lower than in patients with CC genotypes (85,5% vs. 100%). The ineffectiveness of AVT according to the scheme peg-IFNα+SOF+RBV was associated with the presence of CG/GG genotypes and the highest concentration of IL-6 in the blood.
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