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Reducing Holomycin Thiosulfonate to its Disulfide with Thiols

Andrew N Chan1, Walter J Wever2, Elisabetta Massolo1

  • 1Department of Chemistry , University of North Carolina at Chapel Hill , CB #3290, Chapel Hill , North Carolina 27599 , United States.

Chemical Research in Toxicology
|December 8, 2018
PubMed
Summary

Dithiolopyrrolone thiosulfonates, like oxo-holomycin, undergo unique redox reactions. They oxidize thiols to disulfides, revealing novel chemistry for these natural products.

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