Related Experiment Video
Updated: Feb 1, 2026
06:51
Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
Published on: February 20, 2021
5.6K
Dosimetry of indigenously developed 177Lu patch source for surface brachytherapy-Experimental and Monte Carlo methods
Sridhar Sahoo1,2, Vandana Shrivastava1, T Palani Selvam1,2
1Radiological Physics & Advisory Division, Bhabha Atomic Research Centre, Mumbai-400 085, India.
Summary
This study evaluated a novel Lutetium-177 (¹⁷⁷Lu) skin patch for non-melanoma skin cancer treatment. Dosimetry measurements and Monte Carlo simulations confirmed its potential for accurate surface dose delivery.
Area of Science:
- Medical Physics
- Radiotherapy
- Nuclear Medicine
Background:
- Non-melanoma skin cancer (NMSC) treatment requires precise surface dose delivery.
- Developing targeted radionuclide therapies for NMSC is an active area of research.
- In-house developed ¹⁷⁷Lu skin patch sources offer a potential new modality.
Purpose of the Study:
- To evaluate the dosimetry characteristics of a novel ¹⁷⁷Lu skin patch source.
- To determine the absorbed dose rate at the surface for NMSC treatment planning.
- To validate measurements using Monte Carlo simulations.
Main Methods:
- Activity measurement of the ¹⁷⁷Lu skin patch source using gamma-ray spectrometry with a high-purity germanium (HPGe) detector.
- Determination of absorbed dose rate to water at 5 μm depth using an extrapolation chamber and EBT3 Gafchromic film.
- Calculation of correction factors and dose profiles using Monte Carlo methods.
Main Results:
- The absorbed dose rate at 5 μm depth was measured as 9.9 ± 0.7 Gy h⁻¹ mCi⁻¹ (extrapolation chamber) and 8.2 ± 0.1 Gy h⁻¹ mCi⁻¹ (EBT3 film).
- Monte Carlo simulations yielded a surface dose rate of 8.7 ± 0.2 Gy h⁻¹ mCi⁻¹, showing good agreement with experimental measurements.
- Depth dose and lateral dose profiles were calculated for treatment planning.
Conclusions:
- The ¹⁷⁷Lu skin patch source exhibits favorable dosimetry characteristics for NMSC treatment.
- Measured dose rates provide essential data for determining appropriate treatment times.
- The study validates the use of Monte Carlo methods for dosimetry assessment of such sources.
Related Concept Videos
01:18Methods of Documentation I: Source-Oriented Records
1.7K
Source-oriented records, or SOR, are medical record-keeping organized by the data source. The SOR system was first developed in the mid-1900s to organize the growing patient data in hospitals and other healthcare facilities.
In an SOR, each discipline involved in patient care maintains a separate medical record section. This record-keeping method enables easy tracking of patient progress and ensures healthcare staff have access to up-to-date information.
Key Attributes include the following:
In an SOR, each discipline involved in patient care maintains a separate medical record section. This record-keeping method enables easy tracking of patient progress and ensures healthcare staff have access to up-to-date information.
Key Attributes include the following:
1.7K
01:21Development of Analytical Methods
2.3K
An analytical methodology can be divided into four sequential steps: technique, method, procedure, and protocol. A technique is a scientific principle that rationalizes a specific phenomenon through chemical measurements. Adapting a technique for analyzing a sample of interest is termed a method. The procedure outlines the directions for performing the analysis via an analytical method. The protocol is the detailed guidelines on the procedure, which should be strictly followed to obtain the...
2.3K
01:02Long-patch Base Excision Repair
8.0K
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
8.0K
01:32The Scientific Method
266.0K
The scientific method is a detailed, empirical problem-solving process used by biologists and other scientists. This iterative approach involves formulating a question based on observation, developing a testable potential explanation for the observation (called a hypothesis), making and testing predictions based on the hypothesis, and using the findings to create new hypotheses and predictions.
Generally, predictions are tested using carefully-designed experiments. Based on the outcome of these...
Generally, predictions are tested using carefully-designed experiments. Based on the outcome of these...
266.0K
01:18Patch Clamp
6.6K
Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
6.6K
01:43Sustainable Development
15.1K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.1K