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Related Experiment Video

Updated: Feb 1, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

Right ventricular undifferentiated pleomorphic sarcoma: A case report.

Jared P Beller¹, Scott Maddalo¹, Ronaldo Zamuco²

¹Department of Cardiothoracic Surgery, New York University School of Medicine, New York, NY, USA.

Journal of Cardiology Cases

|December 8, 2018

Summary

This summary is machine-generated.

Undifferentiated pleomorphic sarcoma (UPS) is a rare cardiac tumor. This case highlights challenges in diagnosing and treating right ventricular UPS, emphasizing the need for accurate histopathology over initial imaging.

Keywords:

Cardiac tumor Right ventricle Sarcoma

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Area of Science:

Oncology
Cardiology
Pathology

Background:

Undifferentiated pleomorphic sarcoma (UPS), formerly malignant fibrous histiocytoma, typically affects extremities, trunk, and retroperitoneum.
Cardiac involvement by UPS is rare, presenting diagnostic challenges due to potential misidentification as benign neoplasms on noninvasive imaging.
Primary cardiac tumors, including UPS, pose significant diagnostic and therapeutic hurdles.

Purpose of the Study:

To present a case of a large right ventricular undifferentiated pleomorphic sarcoma.
To discuss the diagnostic difficulties and treatment strategies for rare cardiac UPS.
To highlight the importance of histopathology in diagnosing cardiac neoplasms.

Main Methods:

Case report of a 57-year-old woman with right ventricular mass.
Preoperative imaging (suggestive of myxoma) and subsequent surgical excision.
Histopathologic evaluation confirming undifferentiated pleomorphic sarcoma.

Main Results:

The patient presented with right-sided heart failure symptoms.
Preoperative imaging mimicked a cardiac myxoma.
Histopathology confirmed UPS; margins were positive, necessitating adjuvant chemotherapy.

Conclusions:

Accurate diagnosis of primary cardiac tumors, such as UPS, is challenging and often requires histopathology.
Surgical resection is standard, but complete removal can be limited by tumor size and location.
Adjuvant therapies are crucial for managing incomplete resections of cardiac UPS.