![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Metal-catalyzed cross-coupling chemistry with polyhedral boranes
Rafal M Dziedzic1, Alexander M Spokoyny
1Department of Chemistry & Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, USA. rdziedzic@chem.ucla.edu spokoyny@chem.ucla.edu.
Chemical Communications (Cambridge, England)
|December 8, 2018
Summary
Metal-catalyzed cross-coupling is now used to functionalize boron-rich clusters, enabling new synthetic routes. This powerful technique allows for the creation of unique boron cluster-based materials for diverse applications.
Area of Science:
- * Inorganic Chemistry
- * Organometallic Chemistry
- * Materials Science
Background:
- * Metal-catalyzed cross-coupling reactions are vital for functionalizing carbon-based molecules.
- * These methodologies are increasingly adapted for inorganic compounds, specifically boron-rich clusters.
- * Synthesis of halogenated boron clusters is crucial for their use as electrophilic partners.
Purpose of the Study:
- * To explore the adaptation of metal-catalyzed cross-coupling for boron-rich clusters.
- * To highlight the unique aspects of boron cluster cross-coupling compared to hydrocarbon chemistry.
- * To demonstrate the broad applicability of this chemistry across various boron-containing systems.
Main Methods:
- * Synthesis of halogenated boron-rich clusters.
- * Application of metal catalysts to facilitate cross-coupling reactions.
- * Utilizing nucleophilic substrates with electrophilic boron cluster partners.
Main Results:
- * Successful adaptation of cross-coupling for neutral and anionic carboranes, metallaboranes, and carbon-free boranes.
- * Demonstrated the unique reactivity of boron-halogen and boron-heteroatom bonds.
- * Enabled boron-heteroatom couplings (C, N, O, P, S).
Conclusions:
- * Metal-catalyzed cross-coupling offers a versatile strategy for functionalizing diverse boron clusters.
- * This chemistry facilitates the synthesis of novel boron cluster-based systems.
- * Applications include ligand design, medicinal chemistry, and advanced materials development.
More Related Videos
Related Concept Videos
02:51Metal-Ligand Bonds
24.3K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.3K
02:58Chemistry of the Cell
48.0K
The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
48.0K
01:34Crossing Over
171.9K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
171.9K
02:32Bonding in Metals
52.4K
Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”.
52.4K
02:37Metallic Solids
20.6K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.6K
03:06Alkali Metals
24.6K
Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
Table 1: Properties of the alkali metals
Table 1: Properties of the alkali metals
24.6K