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Related Concept Videos

Alkali Metals03:06

Alkali Metals

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Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
Table 1: Properties of the alkali metals
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Bonding in Metals02:32

Bonding in Metals

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Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”. 
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Metallic Solids02:37

Metallic Solids

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Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
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Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Organic Compounds03:02

Organic Compounds

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All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
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Properties of Transition Metals02:58

Properties of Transition Metals

29.8K
Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
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Author Spotlight: Characterizing Porous Materials for Aiding the Development of Robust Metal-Organic Frameworks with Adsorption Behavior
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Metal-Organic-Framework-Based Enzymatic Microfluidic Biosensor via Surface Patterning and Biomineralization.

Munirah Mohammad, Amir Razmjou1, Kang Liang

  • 1Department of Biotechnology, Faculty of Advanced Sciences and Technologies , University of Isfahan , Isfahan 73441-81746 , Iran.

ACS Applied Materials & Interfaces
|December 12, 2018
PubMed
Summary

This study develops a novel enzyme-metal-organic-framework (MOF) biosensor for glucose detection. The patterned enzyme-MOF in microfluidics shows enhanced stability and a wide linear response range, paving the way for advanced diagnostic devices.

Keywords:
biosensorsenzymesmetal−organic frameworkmicrofluidicpatterningpolydopaminepumpless transportation

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Area of Science:

  • Materials Science
  • Biotechnology
  • Analytical Chemistry

Background:

  • Enzyme-metal-organic-framework (MOF) composites enhance enzyme stability for biosensing.
  • Current methods often require post-synthesis immobilization, limiting flexibility.
  • Microfluidic systems and surface patterning offer advantages for diagnostic devices.

Purpose of the Study:

  • To develop a patterned enzyme-MOF biosensor for glucose detection.
  • To utilize mussel-inspired coatings and microfluidics for enzyme immobilization.
  • To investigate the stability and performance of the in situ composite.

Main Methods:

  • Fabrication of patterned zeolitic imidazole framework-8 (ZIF-8) thin films with glucose oxidase (GOx) and horseradish peroxidase (HRP) on polydopamine/polyethyleneimine (PDA/PEI) coated microfluidic channels.
  • Utilizing a wettability gradient for "pumpless transportation" of reagents.
  • Assessing the stability, selectivity, sensitivity, and limit of detection for glucose.

Main Results:

  • The ZIF-8/GOx&HRP in situ composites exhibited improved acid and thermal stability compared to controls.
  • The biosensor demonstrated high selectivity towards glucose with a linear sensitivity of 0.00303 Abs/μM.
  • A low limit of detection (8 μM) and an extended linear response range (8 μM to 5 mM) were achieved due to the diffusion-limiting effect of the ZIF-8 thin film.

Conclusions:

  • Surface patterning of enzyme-MOF composites in microfluidics offers a flexible approach for biosensor development.
  • The ZIF-8/GOx&HRP system provides enhanced stability and performance for glucose detection.
  • This technique holds potential for integrating other biomolecules like antibodies and aptamers for diverse biosensing applications.