Related Experiment Video
Updated: Feb 1, 2026
08:45
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
14.2K
Thesaurus for off-label indications for systemic antifungal agents.
A L Bienvenu1, M Aussedat2, F Maldonado3
1Service pharmacie, groupement hospitalier Nord, hospices civils de Lyon, Lyon, France; UMR-CNRS 5246, campus Lyon La Doua, université de Lyon, Lyon, France; Comité des anti-infectieux, hospices civils de Lyon, Lyon, France.
Medecine Et Maladies Infectieuses
|December 12, 2018
Summary
A new thesaurus was created to guide off-label antifungal use, improving clinical practices and controlling prescriptions. This tool aids in managing complex invasive fungal infections.
Area of Science:
- Medical Mycology
- Clinical Pharmacy
- Infectious Diseases
Background:
- Off-label prescriptions for systemic antifungals require careful management to ensure patient safety and optimize treatment outcomes.
- Existing clinical practices lacked a standardized approach for reviewing and approving non-standard antifungal indications.
- The development of this thesaurus was integrated into an existing antifungal stewardship program.
Purpose of the Study:
- To develop a comprehensive thesaurus for off-label indications of systemic antifungals.
- To update clinical practices related to antifungal prescribing.
- To establish a system for controlling and reviewing off-label antifungal use.
Main Methods:
- Analysis of clinical practice guidelines and relevant literature.
- Validation of off-label terminology (prophylaxis, preemptive, empirical, curative) by a multidisciplinary expert group.
- Integration with institutional drug use and anti-infective committees.
Main Results:
- A validated thesaurus detailing off-label antifungal indications, corresponding agents, and supporting references was established.
- The thesaurus was approved by a multidisciplinary group for antifungal agents.
- The initiative supports an ongoing antifungal stewardship program.
Conclusions:
- The developed thesaurus serves as a valuable tool for reviewing off-label antifungal prescriptions.
- Its implementation is crucial for managing complex invasive fungal infections effectively.
- Sharing this resource can enhance consistency and safety in antifungal therapy nationwide.
Related Concept Videos
02:39Indicators
60.7K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
60.7K
01:29Mechanical Ventilation I: Indication and Settings
2.8K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.8K
01:19Respiratory Assessment: Purpose and Indications
1.8K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.8K
01:18Second Order systems II
406
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
406
01:29Subviral Agents
563
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
563
01:21First Order Systems
428
First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
428