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Physical Activity Is Associated with Attenuated Disease Progression in Chronic Obstructive Pulmonary Disease
Heleen Demeyer1,2,3,4, David Donaire-Gonzalez1,2,3, Elena Gimeno-Santos3,5
1ISGlobal, Barcelona, SPAIN.
Medicine and Science in Sports and Exercise
|December 12, 2018
Summary
Higher physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD) slows lung function decline and reduces symptom worsening. This finding highlights the importance of PA for managing COPD progression.
Area of Science:
- Pulmonary Medicine
- Respiratory Health
- Exercise Physiology
Background:
- Chronic obstructive pulmonary disease (COPD) is characterized by progressive decline in lung function and exercise capacity.
- Disease progression impacts multiple domains, including muscle strength, body composition, and health status.
- The longitudinal impact of physical activity (PA) on these diverse components of COPD progression requires further investigation.
Purpose of the Study:
- To assess the longitudinal association between physical activity (PA) and key components of chronic obstructive pulmonary disease (COPD) progression.
- To determine if higher baseline PA attenuates the decline in lung function, exercise capacity, muscle strength, health status, and body composition in COPD patients.
Main Methods:
- A cohort of 114 COPD patients (PAC-COPD) were followed for an average of 2.6 years.
- Baseline physical activity was objectively measured using accelerometry.
- Multivariable general linear models were employed to analyze the association between PA and changes in disease parameters, adjusting for confounders and baseline values.
Main Results:
- Each 1000 steps/day increase in baseline PA was associated with a slower decline in forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC).
- Higher PA correlated with a slower decline in carbon monoxide diffusing capacity and less deterioration in the St George's Respiratory Questionnaire symptom domain.
- No significant associations were found between PA and changes in functional exercise capacity, muscle strength, other health status domains, or body composition.
Conclusions:
- Increased physical activity is linked to a slower rate of lung function decline in COPD patients.
- Higher PA also mitigates the worsening of symptoms as measured by the St George's Respiratory Questionnaire.
- These findings underscore the protective role of physical activity in managing COPD progression, particularly concerning lung function and symptom burden.
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