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Altered Spontaneous Brain Activity in Patients with Classical Trigeminal Neuralgia Using Regional Homogeneity: A
Chu-Qi Xiang1, Wen-Feng Liu1, Qian-Hui Xu1
1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang, Jiangxi, China.
Pain Practice : the Official Journal of World Institute of Pain
|December 12, 2018
Summary
Patients with classical trigeminal neuralgia (CTN) show altered brain activity in specific regions, as indicated by regional homogeneity (ReHo) analysis. These findings suggest CTN impacts overall cerebral function, though no direct correlation with clinical symptoms was observed.
Area of Science:
- Neuroimaging
- Neurology
- Radiology
Background:
- Neuroimaging studies reveal altered neuronal activity and structure in pain conditions.
- Classical trigeminal neuralgia (CTN) is a pain disorder affecting cranial nerves.
Purpose of the Study:
- To investigate neuronal activity changes in CTN patients using regional homogeneity (ReHo).
- To assess if ReHo values can differentiate CTN patients from healthy controls.
- To explore correlations between ReHo values and clinical manifestations in CTN.
Main Methods:
- Functional magnetic resonance imaging (fMRI) was used for 28 CTN patients and 28 controls.
- Regional homogeneity (ReHo) analysis assessed neural activity consistency.
- Receiver operating characteristic (ROC) curves and Pearson's correlation were employed.
Main Results:
- CTN patients exhibited increased ReHo in the cerebellum, temporal gyrus, occipital gyrus, fusiform gyrus, frontal gyrus, and precentral gyrus compared to controls.
- ROC analysis demonstrated high accuracy in differentiating CTN patients based on ReHo values.
- No significant correlation was found between ReHo values and clinical symptoms in CTN patients.
Conclusions:
- CTN is linked to altered neuronal networks across various brain regions.
- Observed changes in ReHo values indicate a significant impact of CTN on cerebral function.
- ReHo analysis shows potential for differentiating CTN patients and understanding disease-related brain alterations.
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