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Cancer Gene Discovery: Past to Present
Christopher R Clark1, Wilaiwan DuRose1, Timothy K Starr2,3
1Department of Ob-Gyn & Women's Health, University of Minnesota, Minneapolis, MN, USA.
Methods in Molecular Biology (Clifton, N.J.)
|December 14, 2018
Summary
Understanding cancer
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Cancer arises from genetic alterations, leading to complex phenotypic changes.
- Current understanding of cancer's molecular mechanisms and hallmarks remains incomplete.
- Precision medicine aims to tailor cancer treatment based on individual tumor genetics.
Purpose of the Study:
- To present protocols for identifying genetic drivers of cancer.
- To deepen the understanding of molecular mechanisms underlying cancer development.
- To facilitate advancements in cancer gene discovery and therapeutic strategies.
Main Methods:
- Utilizing in silico, in vitro, and in vivo techniques.
- Focusing on identifying genetic drivers of cancer.
- Providing a historical overview of cancer gene discovery.
Main Results:
- The book chapters detail various methodologies for cancer research.
- Protocols are provided to aid researchers in identifying cancer's genetic underpinnings.
- The study aims to contribute to the growing knowledge base of cancer mechanisms.
Conclusions:
- Knowledge of genetic changes, including oncogenes and tumor suppressors, is vital for advancing cancer therapies.
- The provided protocols can be instrumental in discovering new cancer drivers.
- This work supports the progression towards more effective, genetically-informed cancer treatments.
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