Related Experiment Video
Updated: Feb 1, 2026
08:56
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
3.5K
Effective Ibuprofen Desensitization in a Patient with Myopericarditis
Gabriele Cortellini1, Domenico Lippolis2, Silvia Amati3
1Internal Medicine, Allergy Unit, Rimini Hospital, Azienda Sanitaria Romagna, Rimini, Italy, gcortellini@libero.it.
Pharmacology
|December 14, 2018
Summary
Aspirin desensitization is common for specific conditions. This study shows successful ibuprofen desensitization in a patient with urticaria, angioedema, pericarditis, and myocarditis.
Area of Science:
- Cardiology
- Immunology
- Pharmacology
Background:
- Aspirin desensitization is established for NSAIDs-exacerbated respiratory disease (NERD) and hypersensitivity reactions in coronary artery disease patients.
- Limited data exist on aspirin desensitization for other cardiac conditions and for different NSAIDs.
Observation:
- A patient presented with urticaria and angioedema, alongside pericarditis and myocarditis.
Findings:
- An effective ibuprofen desensitization protocol was successfully implemented for this patient.
- This represents a novel application of NSAID desensitization beyond established indications.
Implications:
- This case suggests potential for NSAID desensitization in managing complex cardiac conditions with associated hypersensitivity.
- Further research is warranted to explore NSAID desensitization in broader cardiological contexts.
More Related Videos
Related Concept Videos
01:12GPCR Desensitization
8.1K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
8.1K
01:20Desensitization and Tachyphylaxis
3.1K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.1K
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
236
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
236
02:19Buffer Effectiveness
55.2K
Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
The buffer capacity is the amount of acid or base that can be added to a given volume...
55.2K
03:26Framing Effects
7.9K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
7.9K
02:59Biological Effects of Radiation
17.9K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.9K