Related Experiment Video
Updated: Feb 1, 2026
10:18
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
14.2K
Fully bioresorbable vascular scaffolds: lessons learned and future directions
Hiroyuki Jinnouchi1, Sho Torii1, Atsushi Sakamoto1
1CVPath Institute, Gaithersburg, MD, USA.
Nature Reviews. Cardiology
|December 15, 2018
Summary
Bioresorbable vascular scaffolds (BVS) aimed to replace metallic stents but faced challenges. Longer-term studies revealed increased thrombosis and revascularization, leading to market withdrawal and a need for improved next-generation devices.
Area of Science:
- Cardiovascular Medicine
- Biomaterials Science
- Interventional Cardiology
Background:
- Metallic drug-eluting stents (DES) pose long-term limitations, including vessel caging and foreign-body responses.
- Fully bioresorbable scaffolds (BRS) were developed as a transient alternative to DES.
- The first FDA-approved BRS, Absorb BVS, initially showed promise but later exhibited disappointing long-term outcomes.
Purpose of the Study:
- To review preclinical and clinical data on BRS, comparing vascular biological reactions to metallic DES.
- To understand how these biological responses influence clinical outcomes.
- To discuss next-generation BRS and necessary modifications for improved long-term efficacy.
Main Methods:
- Comprehensive review of existing preclinical and clinical studies on bioresorbable vascular scaffolds.
- Comparative analysis of vascular biological responses to BRS versus metallic drug-eluting stents.
- Evaluation of clinical outcomes, including device thrombosis and target-lesion revascularization.
Main Results:
- Early BRS studies showed positive short-term outcomes, but longer-term follow-up revealed increased rates of device thrombosis and target-lesion revascularization.
- The Absorb BVS device was withdrawn from the market due to low demand, linked to these adverse outcomes.
- Vascular biological reactions to BRS differ from those to metallic DES, impacting clinical performance.
Conclusions:
- Current BRS designs require significant modifications to improve long-term safety and efficacy.
- Further research into next-generation BRS is crucial for their viability as a treatment option.
- Addressing the biological challenges associated with BRS is key to realizing their potential in treating coronary artery disease.
Related Concept Videos
03:24Seedless Vascular Plants
66.8K
Seedless Vascular Plants Were the First Tall Plants on Earth
66.8K
01:14Avoidance Learning and Learned Helplessness
2.6K
Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
2.6K
01:27Associative Learning
1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
Classical conditioning, also known...
1.3K
01:22Purposive Learning
503
E. C. Tolman emphasized the purposiveness of behavior — the idea that much of our behavior is goal-directed. For instance, employees who aim for a promotion work diligently to meet their targets. Tolman argued that when classical conditioning and operant conditioning occur, the organism acquires certain expectations. In classical conditioning, a child might fear a dog because they expect it to bite. In operant conditioning, a person might consistently work overtime because they expect a...
503
01:12Observational Learning
973
Albert Bandura's observational learning, also known as imitation or modeling, occurs when a person observes and imitates another's behavior. It is a quicker process than operant conditioning. A well-known example is the Bobo doll study, where children who saw an adult acting aggressively towards the doll were more likely to act aggressively when left alone, compared to those who observed a nonaggressive adult. Many psychologists view observational learning as a form of latent learning...
973
01:25Learning Disabilities
611
Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...
Dyslexia
Dyslexia is a...
611