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Published on: April 30, 2020
[Effects of glucagon-like peptides on gallbladder motility]
Ida M Gether1, Christina Nexøe-Larsen, David P Sonne
1filipknop@dadlnet.dk.
Abstract:
As cases of gallbladder-related adverse events have been reported in patients treated with glucagon-like peptide (GLP)-1 receptor agonists and GLP-2 receptor agonists, studies have investigated the effects of these hormones on the enterohepatic circulation of bile acids and gallbladder motility. Results suggest, that bile acids and GLP-2 counteract postprandial cholecystokinin-mediated gallbladder contraction, while GLP-1 may delay gallbladder refilling. This provides important information on the effect and safety of drugs based on GLP-1 and GLP-2, respectively.
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