Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

23.3K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
23.3K
Structure of Blood Vessels01:15

Structure of Blood Vessels

9.4K
Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
9.4K
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.1K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.1K
Protein Networks02:26

Protein Networks

4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Network Covalent Solids02:18

Network Covalent Solids

16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

17.5K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
17.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NRAS<sup>Q61R</sup> Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis.

Pediatric blood & cancer·2026
Same author

Lymphatic Malformations With Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Guidelines for evaluating endothelial function in vascular tissue.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Estimation of 3D wall shear stress in new blood vessel sprouts using high-fidelity simulations.

Biophysical journal·2026
Same author

From blood vessels to lymphatics and back again.

Function (Oxford, England)·2025
Same author

Heavy alcohol consumption attenuates human mesenteric artery responsiveness to sigma receptor-1 ligands.

American journal of physiology. Heart and circulatory physiology·2025
Same journal

SLIT-ROBO Signaling in Diabetes: A Dual Regulator of Angiogenesis and Vascular Dysfunction.

Comprehensive Physiology·2026
Same journal

Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.

Comprehensive Physiology·2026
Same journal

The Adipose-Organ Communication Network in Clinical Obesity: From Adiposopathy to Systemic Metabolic Failure.

Comprehensive Physiology·2026
Same journal

Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.

Comprehensive Physiology·2026
Same journal

Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential.

Comprehensive Physiology·2026
Same journal

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases.

Comprehensive Physiology·2026
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

7.0K

Lymphatic Vessel Network Structure and Physiology.

Jerome W Breslin1, Ying Yang1, Joshua P Scallan1

  • 1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.

Comprehensive Physiology
|December 15, 2018
PubMed
Summary
This summary is machine-generated.

The lymphatic system maintains tissue health and immunity by managing fluid balance and removing waste. This review covers its anatomy, physiology, and role in disease.

More Related Videos

Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics
08:08

Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics

Published on: December 8, 2011

14.1K
Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
09:52

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Published on: March 8, 2013

16.9K

Related Experiment Videos

Last Updated: Feb 1, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

7.0K
Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics
08:08

Measurement of Cytosolic Ca2+ in Isolated Contractile Lymphatics

Published on: December 8, 2011

14.1K
Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
09:52

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

Published on: March 8, 2013

16.9K

Area of Science:

  • Physiology
  • Immunology
  • Anatomy

Background:

  • The lymphatic system is crucial for maintaining tissue homeostasis and immune surveillance.
  • It comprises a network of vessels and lymphoid tissues essential for fluid balance and defense against pathogens.

Purpose of the Study:

  • To provide a comprehensive review of the lymphatic system's anatomy and physiology.
  • To highlight key findings from the past century and recent advances in lymphatic research.
  • To explore the role of lymphatics in various diseases.

Main Methods:

  • Literature review of historical and contemporary research on lymphatic vessels.
  • Analysis of studies on lymphatic system development, function, and disease pathology.
  • Synthesis of information on tissue/organ specificity, lymph formation, transport, and lymphangiogenesis.

Main Results:

  • The lymphatic system is vital for extracellular fluid homeostasis and optimal tissue function.
  • It plays a critical role in immune responses against bacteria, viruses, and parasites.
  • Recent advances have expanded our understanding of lymphatic vessel development and function.

Conclusions:

  • The lymphatic system's intricate network is fundamental to maintaining physiological balance and health.
  • Dysfunction of lymphatic vessels is implicated in numerous disease states.
  • Continued research into lymphatic physiology and pathology holds promise for therapeutic interventions.