[Study on the relationship between neutrophil lymphocyte ratio and platelet lymphocyte ratio and sudden deafness]

Objective: To investigate the relationship between neutrophil lymphocyte ratio(NLR) and platelet lymphocyte ratio(PLR) and the incidence of sudden deafness and its impact on the prognosis. Method: The clinical data of 203 patients with sudden deafness was retrospectively analyzed.Pure tone audiometry, complete blood count and other related examinations were performed before treatment. Hearing type was depending on the diagnostic criteria of sudden deafness; NLR and PLR were calculated. After that, pure tone audiometry was reviewed again and the hearing changes were recorded.The control group was 203 healthy persons without infectious disease. Result: The median NLR and PLR of the sudden deafness group were 2.8 and 126.4, respectively, and that of the control group were 1.4 and 96.9 respectively.The difference between the two groups was statistically significant(P<0.01). The median NLR and PLR of the recovery group were 2.4 and 116.9, and that of the unrecovered group were 3.4 and 145.0,respectively, the difference between the two groups was statistically significant (P<0.05). No significant difference of NLR or PLR was observed among the low medium frequency type, high frequency type, flat type and total deafness type for each two pairs(P>0.05). Conclusion: NLR and PLR are higher in patients with sudden deafness than the healthy controls, and are higher in the unrecovered group than in the recovery group. Our result supports the role of inflammatory theory in the pathogenesis of sudden deafness.Therefore, NLR and PLR can be used as a new reliable indicator to evaluate the prognosis of sudden deafness, but NLR and PLR may not have a significant correlation with hearing classification.