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Updated: Feb 1, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.8K

[MicroRNA and sensorineural hearing loss]

X L Tang, Y Li, L F Jia

    Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery
    |December 15, 2018
    PubMed

    Insights

    Sensorineural hearing loss stems from inner ear damage. MicroRNAs are increasingly recognized for their crucial role in regulating gene expression and contributing to the development of this hearing impairment.

    Area of Science:

    • Genetics
    • Molecular Biology
    • Otolaryngology

    Context:

    • Sensorineural hearing loss (SNHL) is a prevalent condition affecting the cochlea or auditory pathway.
    • Damage to the inner ear's sensory epithelium is a primary pathological hallmark of SNHL.
    • The causes of SNHL are intricate and varied, necessitating a deeper understanding of underlying molecular mechanisms.

    Purpose:

    • To review the multifaceted role of microRNAs in the pathogenesis of sensorineural hearing loss.
    • To elucidate how microRNAs regulate gene expression relevant to inner ear development and function.
    • To consolidate current research on microRNA involvement in SNHL etiology.

    Summary:

    • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally.
    • Dysregulation of specific miRNAs has been implicated in the cellular damage characteristic of SNHL.
    • This review synthesizes evidence linking miRNA activity to the development and progression of sensorineural deafness.

    Impact:

    • Highlights the significance of microRNAs as potential diagnostic biomarkers for SNHL.
    • Suggests microRNAs as therapeutic targets for future interventions against hearing loss.
    • Provides a comprehensive overview for researchers investigating the molecular basis of auditory disorders.
    Keywords:
    hearing loss,sensorineuralmicroRNA

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