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Published on: June 3, 2022
Combination of OPSY and PhD-PHIP results in enhanced sensitivity in PHIP
S Bussandri1, L Buljubasich1, R H Acosta1
1Universidad Nacional de Córdoba, Facultad de Matemática, Atronomía, Física y Computación, Córdoba, Argentina; CONICET, Instituto de Física Enrique Gaviola (IFEG), Córdoba, Argentina.
Abstract:
Despite the large degree of polarization in PHIP experiments compared to the Boltzmann factor, the presence of a large amount of non-reacted molecules with thermal polarization is an important obstacle when dealing with very diluted samples. The feasibility of enhancing both sensitivity and resolution in a single experiment by combining two well established pulse sequences, OPSY and PHD-PHIP is presented. OPSY is used as a block for filtering the signals originated from thermally polarized protons. PhD-PHIP, on the other hand, is used as an acquisition block, increasing the resolution and further improving the sensitivity by preventing signal canceling in the presence of magnetic field inhomogeneities. Experiments in a complex sample with very low hyperpolarization levels are presented showing the excellent performance of the method.
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