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Mitral Chordae Rupture as a Possible First-Time Presentation for Graves’ Disease

Sami N Ghazal1, Mohammad K Alarfaj2

  • 1Imam Abdulrahman bin Faisal University, College of Medicine, Internal Medicine Department, Saudi Arabia.

The Journal of Heart Valve Disease
|December 19, 2018
PubMed

Insights

Graves' disease, a common cause of hyperthyroidism, can rarely cause heart valve damage. This case highlights a rare mitral valve complication linked to Graves' disease and rapid heart function.

Area of Science:

  • Cardiology
  • Endocrinology
  • Valvular Heart Disease

Background:

  • Graves' disease is an autoimmune disorder causing hyperthyroidism.
  • Hyperthyroidism can lead to significant cardiovascular complications.
  • Mitral valve disease is a potential, though infrequent, complication.

Observation:

  • A 44-year-old male presented with new-onset atrial fibrillation.
  • The patient also exhibited mitral regurgitation due to flail anterior mitral leaflet with chordae tendineae rupture.
  • This specific cardiac complication is exceptionally rare in Graves' disease.

Findings:

  • The observed mitral valve complication is only the third reported instance in association with Graves' disease.
  • A hypothesis suggests Graves'-associated myxomatous degeneration of the mitral valve.
  • This degeneration may be exacerbated by a hyperdynamic circulatory state.

Implications:

  • This case underscores the importance of cardiac monitoring in patients with Graves' disease.
  • Understanding the mechanism may prevent rare but severe cardiovascular events.
  • Further research into the link between autoimmune thyroid disease and valvular degeneration is warranted.

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