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Glaucoma secondary to intraocular tumors: mechanisms and management

David A Camp1, Prashant Yadav1, Lauren A Dalvin1,2

  • 1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Current Opinion in Ophthalmology
|December 19, 2018
PubMed
Abstract

Insights

Intraocular tumors can cause secondary glaucoma through various mechanisms. Treating the primary tumor is key, with medical, laser, or surgical interventions for glaucoma, avoiding certain surgeries in active malignancy.

Area of Science:

  • Ophthalmology
  • Oncology

Background:

  • Secondary glaucoma is a significant complication of intraocular tumors.
  • Early consideration is crucial for patients with known tumors or unexplained unilateral/refractory glaucoma.

Purpose of the Study:

  • To review the mechanisms by which intraocular tumors cause secondary glaucoma.
  • To discuss current management strategies for these cases.

Main Methods:

  • Literature review of intraocular tumors associated with secondary glaucoma.
  • Analysis of tumor-related glaucoma mechanisms and treatment outcomes.

Main Results:

  • Common culprits include iris melanoma, choroidal melanoma, retinoblastoma, and others.
  • Glaucoma mechanisms involve tumor invasion, angle closure, and neovascularization.
  • Tumor treatment can resolve glaucoma; management includes medical, laser, and specific surgical approaches.

Conclusions:

  • Intraocular tumors frequently lead to secondary glaucoma.
  • Treatment of the primary malignancy is paramount for glaucoma resolution.
  • Careful selection of glaucoma treatment is necessary, avoiding certain procedures in active tumors.

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