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Updated: Jan 31, 2026
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Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
Published on: October 2, 2014
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Pediatric primary cutaneous blastomycosis clinically responsive to itraconazole
Isabelle M Sanchez1, Lorelei E DiTommaso2, Michelle Bain2
1College of Medicine, University of Illinois at Chicago, USA.
Cutis
|December 20, 2018
Summary
Primary cutaneous blastomycosis is a rare fungal infection in children. This case highlights successful treatment of a 16-year-old with itraconazole, leading to lesion healing.
Area of Science:
- Mycology
- Dermatology
- Infectious Diseases
Background:
- Primary cutaneous blastomycosis is an uncommon fungal infection.
- It is particularly rare in pediatric populations.
- Blastomyces dermatitidis is the causative agent, found in endemic regions.
Observation:
- A 16-year-old immunocompetent male presented with a skin lesion.
- The infection occurred after trauma (falling into a flowerbed).
- The patient resided in a Blastomyces dermatitidis hyperendemic area.
Findings:
- The patient received a 6-month course of itraconazole.
- Treatment involved an initial loading dose followed by a maintenance dose.
- Complete healing of the cutaneous lesion was achieved.
Implications:
- This case demonstrates effective treatment of primary cutaneous blastomycosis in an adolescent.
- It highlights the importance of considering fungal infections in endemic areas.
- Successful management with itraconazole resulted in minimal residual skin dyschromia.
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