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Updated: Jan 31, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
Development of Pd/Polyoxometalate/nitrogen-doping hollow carbon spheres tricomponent nanohybrids: A selective
Lei Wang1, Tianjiao Meng1, Jingjing Sun1
1Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Environmental Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, 071002 Baoding, PR China.
Abstract:
The preparation of palladium nanoparticles (Pd NPs) attached on nitrogen-doping hollow carbon spheres (NHCSs) surface using polyoxometalates (POMs) as both the reductant and bridging molecules by a green strategy was described in this paper. The samples have been thoroughly comprehensive characterized using scanning electron microscopy, transmission electron microscopy, powder X-ray diffraction, energy-dispersive X-ray spectra, and X-ray photoelectron spectroscopy. The as-prepared Pd/POMs/NHCSs tri-component nanohybrids provide enhanced electro-catalytic activities for oxidation of acetaminophen (AP) with the catalytic rate constant (kcat) of 2.34 × 103 M-1s-1 and diffusion coefficient (D) of 6.18 × 10-5 cm2s-1, because of the synergetic effects of Pd NPs and NHCSs. We assessed the use of Pd/POMs/NHCSs as an effective sensing template for electrochemical detection of AP, which showed high analytical performance, such as a linear range of 0.02 μM-0.63 μM with a sensitivity of 508.46 μAmM-1; a linear range of 0.63 μM to 0.083 mM with a sensitivity of 154.27 μAmM-1, and a low limit of detection of 3 nM. This strategy provides a new direction opportunity to promote the electrochemical performance of AP.
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