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Fabrication and Design of Wood-Based High-Performance Composites
Published on: November 9, 2019
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Lignans with melanogenesis effects from Premna serratifolia wood
So-Yeun Woo1, Shotaro Hoshino2, Chin Piow Wong1
1Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.
Fitoterapia
|December 21, 2018
Summary
This study isolated new lignoids from Premna serratifolia wood. Several compounds, including premnan A and premnan C, demonstrated significant melanogenesis-enhancing activities in melanoma cells.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Dermatology
Background:
- Premna serratifolia is a traditional cosmetic plant in Myanmar.
- Lignoids are a class of natural compounds with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new lignoids from Premna serratifolia.
- To evaluate the melanogenesis-promoting effects of isolated compounds.
Main Methods:
- Isolation and purification of lignoids using chromatographic techniques.
- Structure elucidation using 1D and 2D NMR, IR spectroscopy, and HRESIMS.
- Determination of absolute configurations via optical rotation and CD spectroscopy.
- In vitro testing of melanogenesis activity on B16-F10 mouse melanoma cell line.
Main Results:
- Three new lignoids (premnan A, premnan B, tauntangyiol C) and one artifact lignoid (premnan C) were identified.
- Compounds 1 (premnan A) and 4 (premnan C) showed melanogenesis enhancement (31% and 50% at 50 μM).
- Compounds 2, 3, and 6 increased melanin production (67%, 30%, and 45% at 100 μM) without cytotoxicity.
Conclusions:
- Premna serratifolia is a source of novel lignoids with potential cosmetic applications.
- Several isolated lignoids possess significant melanogenesis-enhancing properties.
- Further research may explore these compounds for skin-lightening or pigmentation therapies.
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