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A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

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A Colonic Perineurioma.

Tomoyuki Otani^1,2, Kinta Hatakeyama^1,2, Emi Ohtani³

¹Department of Diagnostic Pathology, Nara Medical University, Kashihara, Japan.

Clinical Medicine Insights. Pathology

|December 22, 2018

Summary

Colonic perineurioma, a rare mesenchymal neoplasm, can be mistaken for other gastrointestinal tumors. This case highlights a polypoid colonic perineurioma, emphasizing accurate diagnosis through immunohistochemistry.

Keywords:

Perineurioma benign fibroblastic polyp colon mesenchymal tumor polypoid

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Area of Science:

Gastrointestinal Pathology
Soft Tissue Neoplasms
Surgical Pathology

Background:

Perineurioma is a mesenchymal neoplasm typically found in soft tissues.
Colonic perineurioma is a rare entity, often encountered in the distal colon.
Misdiagnosis is a risk due to similarity with common gastrointestinal spindle cell neoplasms.

Purpose of the Study:

To describe a case of colonic perineurioma with polypoid intraluminal growth.
To emphasize the importance of recognizing colonic perineurioma to avoid misdiagnosis.
To present the diagnostic features of this rare colonic neoplasm.

Main Methods:

Case report of a patient undergoing follow-up colonoscopy.
Endoscopic resection of a sigmoid colon polyp.
Microscopic examination and immunohistochemical analysis of the resected lesion.

Main Results:

A 6-mm polypoid lesion was identified in the sigmoid colon.
Microscopic examination revealed bland spindle cells in the lamina propria mucosae.
Immunohistochemistry was positive for epithelial membrane antigen, claudin 1, and glucose transporter-1, confirming perineurioma.

Conclusions:

Colonic perineurioma is a rare differential diagnosis for gastrointestinal spindle cell lesions.
Accurate diagnosis requires awareness and specific immunohistochemical markers.
This case illustrates a polypoid presentation of colonic perineurioma.