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Which Index for Muscle Mass Represents an Aging Process?
Hyung-Kook Kim1, You Jin Lee2, Young-Kyun Lee1
1Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Journal of Bone Metabolism
|December 22, 2018
Summary
The body mass index-adjusted muscle mass index (ASM/BMI) effectively represents aging, unlike other muscle mass indices. This finding is crucial for understanding age-related decline and sarcopenia progression.
Area of Science:
- Gerontology
- Muscle Physiology
- Biometrics
Background:
- Sarcopenia research is growing, but the best muscle mass index for tracking aging remains debated.
- Existing indices like appendicular skeletal muscle mass (ASM)/weight and ASM/height² may not accurately reflect age-related physiological changes.
Purpose of the Study:
- To compare three muscle mass indices: ASM/weight, ASM/height², and ASM/BMI.
- To determine which index best correlates with age-related declines in bone mineral density, visual acuity, hearing, renal function, pulmonary function, and handgrip strength.
Main Methods:
- A retrospective cross-sectional study analyzed data from 14,415 men and 17,971 women (aged ≥10 years) from the 2008-2011 Korea National Health and Nutrition Examination Survey.
- Changes in three muscle mass indices were plotted and compared against age-group specific changes in various physiological markers.
Main Results:
- The ASM/BMI demonstrated changes consistent with aging markers.
- ASM/weight and ASM/height² showed no significant correlation with these aging markers.
Conclusions:
- The ASM/BMI is the only tested muscle index that accurately represents the aging process.
- This suggests ASM/BMI may be a more reliable indicator for sarcopenia and age-related health assessments.
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