Iron-Catalyzed Oxyalkylation of Terminal Alkynes with Alkyl Iodides
Weili Deng1, Changqing Ye2, Yajun Li2
1Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, College of Life Sciences , Fujian Normal University , 1 Keji Road , Fuzhou 350117 , P. R. China.
Abstract:
A general oxyalkylation of terminal alkynes enabled by iron catalysis has been developed. Primary and secondary alkyl iodides acted as the alkylating reagents and afforded a range of α-alkylated ketones under mild reaction conditions. Acetyl tert-butyl peroxide (TBPA) was used as the radical relay precursor, providing the initiated methyl radical to start the radical relay process. Preliminary mechanistic studies were conducted, and late-stage functionalizations of natural product derivatives were performed.
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