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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
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Re-emergence of Corynebacterium diphtheriae
C Scheifer1, C Rolland-Debord2, E Badell3
1Groupe hospitalier Pitié-Salpêtrière Charles-Foix, Assistance publique-Hôpitaux de Paris, 73013 Paris, France.
Medecine Et Maladies Infectieuses
|December 26, 2018
Summary
Diphtheria re-emergence is noted in Europe. Two Corynebacterium diphtheriae cases, one cutaneous and one respiratory, were observed in France in 2016.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Diphtheria cases are increasing in Europe, with 53 reported between 2000-2009 and 36 in 2015.
- This highlights a concerning trend of diphtheria re-emergence on the continent.
Observation:
- Two cases of Corynebacterium diphtheriae infection were documented in a French hospital in 2016.
- One case involved a French traveler with a cutaneous infection (toxin-negative).
- The second case was an Afghan refugee with respiratory diphtheria carriage (toxin-positive), who also had pulmonary tuberculosis.
Findings:
- The study presents two distinct presentations of diphtheria infection.
- One case highlights non-toxigenic cutaneous diphtheria in a traveler.
- The other case demonstrates toxigenic respiratory diphtheria carriage in an immunocompromised refugee.
Implications:
- These cases underscore the importance of vigilance for diphtheria in diverse patient populations.
- The re-emergence necessitates reinforced public health surveillance and vaccination strategies.
- Further investigation into the transmission dynamics and risk factors for diphtheria in Europe is warranted.
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