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Updated: Jan 31, 2026

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
Published on: September 11, 2011
Ultra-low dose CT colonography with automatic tube current modulation and sinogram-affirmed iterative reconstruction:
Roberta Cianci1, Andrea Delli Pizzi1, Gianluigi Esposito1
1Department of Neuroscience Imaging and Clinical Sciences, University "G. d'Annunzio", SS. Annunziata Hospital, Chieti, Italy.
Objective:
To assess the radiation dose and image quality of ultra-low dose (ULD)-CT colonography (CTC) obtained with the combined use of automatic tube current (mAs) modulation with a quality reference mAs of 25 and sinogram-affirmed iterative reconstruction (SAFIRE), compared to low-dose (LD) CTC acquired with a quality reference mAs of 55 and reconstructed with filtered back projection (FBP).
Methods:
Eighty-two patients underwent ULD-CTC acquisition in prone position and LD-CTC acquisition in supine position. Both ULD-CTC and LD-CTC protocols were compared in terms of radiation dose [weighted volume computed tomography dose index (CTDIvol ) and effective dose], image noise, image quality, and polyp detection.
Results:
The mean effective dose of ULD-CTC was significantly lower than that of LD-CTC (0.98 and 2.69 mSv respectively, P < 0.0001) with an overall dose reduction of 63.2%. Image noise was comparable between ULD-CTC and LD-CTC (28.6 and 29.8 respectively, P = 0.09). There was no relevant difference when comparing image quality scores and polyp detection for both 2D and 3D images.
Conclusion:
ULD-CTC allows to significantly reduce the radiation dose without meaningful image quality degradation compared to LD-CTC.
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