Related Experiment Video
Updated: Jan 31, 2026
09:16
Studying the Stoichiometry of Epidermal Growth Factor Receptor in Intact Cells using Correlative Microscopy
Published on: September 11, 2015
8.7K
Growth Patterns in Small for Gestational Age Babies and Correlation with Insulin-like Growth Factor-1 Levels
Deepika Rustogi1, Sangeeta Yadav2, Siddarth Ramji3
1Department of Pediatrics,Maulana Azad Medical College (University of Delhi), New Delhi, India.
Indian Pediatrics
|December 28, 2018
Summary
Most Small for Gestational Age babies experience catch-up growth by 18 months, with higher Insulin-like Growth Factor-1 (IGF-1) levels correlating positively with this growth. This suggests IGF-1 is a key indicator in monitoring SGA infant development.
Area of Science:
- Pediatrics
- Endocrinology
- Neonatology
Background:
- Small for Gestational Age (SGA) infants often face growth challenges.
- Insulin-like Growth Factor-1 (IGF-1) plays a crucial role in childhood growth.
- Understanding factors influencing catch-up growth in SGA is vital for early intervention.
Purpose of the Study:
- To investigate the correlation between catch-up growth and Insulin-like Growth Factor-1 (IGF-1) levels in infants born Small for Gestational Age (SGA).
- To assess the prevalence of catch-up growth in SGA infants by 18 months of age.
Main Methods:
- Fifty full-term SGA infants aged 12-18 months were enrolled.
- Catch-up growth was defined as a gain in weight and/or length Standard Deviation Score (SDS) >0.67.
- IGF-1 levels were measured using ELISA post-glucose load and correlated with growth parameters.
Main Results:
- Catch-up growth was observed in 60% of the SGA infants by 18 months.
- IGF-1 levels were significantly higher in infants achieving catch-up growth compared to those who did not.
- A positive correlation was found between IGF-1 levels and both weight and length catch-up.
Conclusions:
- The majority of SGA infants demonstrate catch-up growth by 18 months.
- Elevated IGF-1 levels are associated with successful catch-up growth in SGA infants.
- IGF-1 may serve as a valuable biomarker for monitoring growth in SGA populations.
More Related Videos
Related Concept Videos
01:29Oxygen Requirements and Growth Patterns
1.4K
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
1.4K
01:28Role of Hematopoietic Growth Factors
3.9K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
3.9K
01:29Factors Influencing Microbial Growth: pH
1.2K
Microorganisms are classified as acidophiles, neutrophiles, or alkaliphiles based on their pH growth preferences, reflecting their adaptations to specific environments. Maintaining a stable intracellular pH is critical for macromolecular stability and enzymatic activity, which can be challenged by external pH variations.Neutrophiles, such as Escherichia coli, grow optimally between pH 5.5 and 8.0. These microorganisms inhabit neutral or slightly acidic environments and employ mechanisms like...
1.2K
00:57Population Growth
28.6K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.6K
01:27Factors Influencing Microbial Growth: Temperature
1.2K
Microorganisms display remarkable adaptations, enabling them to thrive in diverse ecological niches across a wide range of temperatures. Temperature profoundly influences microbial growth by affecting enzymatic activity, membrane fluidity, and other cellular processes.Each microorganism operates within a specific temperature range defined by three cardinal points: minimum, optimum, and maximum. Below the minimum temperature, membranes lose fluidity, halting transport processes. Above the...
1.2K
01:28Factors Influencing Microbial Growth: Osmolarity
870
Osmolarity is the measure of solute concentration in a solution. It plays a critical role in determining water availability for organisms. Water moves across semipermeable membranes through osmosis, flowing from regions of lower solute concentration (more dilute) to regions of higher solute concentration (more concentrated).In high-solute environments, microbial cells lose water, leading to dehydration and inhibited growth. The extent to which water is available to microbes in such environments...
870