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[Metaplastic Thymoma;Report of a Case]
Kenji Miura1, Toshihiko Sakamoto
1Department of Thoracic Surgery, Japanese Red Cross Kobe Hospital, Kobe, Japan.
Kyobu Geka. the Japanese Journal of Thoracic Surgery
|December 28, 2018
Summary
A rare biphasic, metaplastic thymoma was identified in a 76-year-old man presenting with an anterior mediastinal nodule. Surgical resection confirmed the diagnosis of this unusual thymoma subtype.
Area of Science:
- Oncology
- Pathology
Background:
- Mediastinal masses can present diagnostic challenges.
- Thymoma is a rare tumor originating from the thymus gland.
Observation:
- A 76-year-old male presented with an anterior mediastinal nodule detected via chest computed tomography (CT).
- The nodule measured 20 mm and was suspected to be a non-invasive thymoma.
Findings:
- Surgical resection revealed a 25×25×13 mm tumor.
- Pathological examination showed a biphasic tumor with polygonal and spindle cell components, exhibiting partial invasion of surrounding tissue.
- Immunohistochemistry was positive for Cytokeratin AE1/3 and epithelial membrane antigen (EMA).
- The final diagnosis was biphasic, metaplastic thymoma.
Implications:
- This case highlights the importance of considering rare thymoma subtypes in the differential diagnosis of anterior mediastinal masses.
- Metaplastic thymomas, particularly biphasic types, require careful pathological evaluation for accurate diagnosis and management.
- Surgical resection remains a primary treatment modality for localized thymomas.
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