Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Relationship Formation02:12

Relationship Formation

46.2K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.2K
Ending Relationships01:28

Ending Relationships

189
The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...
189
Relationship Growth01:27

Relationship Growth

218
Interpersonal relationships progress through stages, beginning with awareness and moving toward mutuality, where emotional connections deepen. While many relationships remain at moderate levels of mutuality, deeper connections form through self-disclosure, trust, and interdependence.Self-DisclosureSelf-disclosure involves revealing personal information, starting with surface-level details and gradually progressing to more intimate content. As trust grows, individuals feel more comfortable...
218
Social Relationships and Well-Being01:30

Social Relationships and Well-Being

311
The significance of social relationships in psychological well-being is a well-established area of inquiry within social psychology. Research consistently demonstrates that the presence of meaningful, supportive relationships enhances emotional health, while the absence or deterioration of such connections can contribute to psychological distress. Relationships serve as a foundation for emotional support, identity, and social belonging, all of which are critical to an individual’s overall...
311
Close Relationships and Culture01:29

Close Relationships and Culture

238
Culture shapes how people approach attraction, choose partners, and build long-term relationships. While some preferences in mate selection appear consistent across cultures, such as men valuing physical attractiveness and women emphasizing financial resources, cultural contexts influence how these preferences are expressed and prioritized. Marriage extends beyond romantic ideals in many societies and is deeply embedded in social, economic, and religious frameworks.The Role of Culture in Mate...
238
Second Order systems II01:18

Second Order systems II

406
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
406

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond co-occurrence: Age, sex, and the temporal progression of autoimmune overlap syndromes in a 23-year nationwide cohort.

Seminars in arthritis and rheumatism·2026
Same author

Machine Learning Model to Predict Postmastectomy Breast Reconstruction Complications.

JAMA network open·2026
Same author

Spinal Cord Ultrasonography Stitching for Detection of Tethered Cord Syndrome.

IEEE transactions on bio-medical engineering·2026
Same author

Minimizing Missed Diagnoses of Tibial Plateau Fractures: The Role of AI in Radiographic Evaluation.

The Journal of bone and joint surgery. American volume·2026
Same author

Assessing the influence of two deep-learning assistance modes on pathologists in cancer identification.

Diagnostic pathology·2026
Same author

Immune Checkpoint Inhibitors Did Not Exacerbate Autoimmune Rheumatic Disease Activity in Patients With Cancer.

Journal of the National Comprehensive Cancer Network : JNCCN·2026

Related Experiment Video

Updated: Jan 31, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

661

Temporal relationships between systemic lupus erythematosus and comorbidities.

Chang-Fu Kuo1,2, I-Jun Chou3,4, Frances Rees1

  • 1Division of Rheumatology, Orthopaedics, and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK.

Rheumatology (Oxford, England)
|December 28, 2018
PubMed
Summary

Systemic lupus erythematosus (SLE) is linked to more health problems before and after diagnosis. These comorbidities significantly increase mortality risk in SLE patients.

Keywords:
Charlson comorbidity indexall-cause mortalitycomorbiditiesepidemiologysystemic lupus erythematosustemporal relationships

More Related Videos

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

18.7K
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

1.0K

Related Experiment Videos

Last Updated: Jan 31, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

661
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

18.7K
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

1.0K

Area of Science:

  • Rheumatology
  • Epidemiology
  • Public Health

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with complex health implications.
  • Understanding the burden of comorbidities associated with SLE is crucial for patient management and prognosis.

Purpose of the Study:

  • To investigate the prevalence and incidence of comorbidities in patients with SLE.
  • To assess the impact of these comorbidities on all-cause mortality in SLE patients.

Main Methods:

  • A UK primary care study identified 1605 incident SLE cases and 6284 matched controls.
  • Comorbidity risks were estimated before (prevalence) and after (incidence) SLE diagnosis.
  • The effect of comorbidities at diagnosis on all-cause mortality was analyzed.

Main Results:

  • SLE diagnosis was associated with higher comorbidity burden, including Charlson Comorbidity Index scores of 1-2, 3-4, and ≥5.
  • Patients with SLE showed an increased risk of developing new comorbidities post-diagnosis.
  • SLE patients faced higher mortality risk, with comorbidities accounting for 27.6% of the excess mortality.

Conclusions:

  • Individuals with SLE experience a significantly increased risk of multiple comorbidities.
  • These comorbidities play a substantial role in the elevated all-cause mortality observed in SLE patients.