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Updated: Jan 31, 2026
11:34
Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Published on: December 5, 2017
13.1K
21-Gene Recurrence Score Testing in HER2-positive Patients
Ariella M Altman1, Schelomo Marmor1, Todd M Tuttle1
1Department of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Clinical Breast Cancer
|January 1, 2019
Summary
Recurrence score (RS) testing is uncommon in HER2-positive breast cancer but influences chemotherapy decisions. Low RS results correlate with reduced chemotherapy use, while high RS indicates higher chemotherapy likelihood.
Area of Science:
- Oncology
- Genomics
- Clinical Decision-Making
Background:
- The 21-gene recurrence score (RS) is validated for ER+, HER2- breast cancer.
- RS testing is not standard for ER+, HER2+ breast cancer patients.
Purpose of the Study:
- Investigate RS testing patterns in ER+, HER2+ breast cancer.
- Analyze RS distributions and their impact on treatment decisions.
Main Methods:
- Utilized Surveillance and Epidemiology End Results database for ER+, HER2+ breast cancer patients.
- Stratified patients by TAILORx RS cutoffs and analyzed treatment characteristics.
- Employed multivariable logistic regression to identify factors associated with RS testing and high-risk RS.
Main Results:
- Only 5% of ER+, HER2+ patients underwent RS testing.
- RS distribution: 17% high-risk, 49% intermediate-risk, 34% low-risk.
- Chemotherapy use varied significantly by RS: 67% (high), 30% (intermediate), 19% (low), compared to 66% in untested patients.
Conclusions:
- RS testing is underutilized in HER2+ early-stage breast cancer.
- RS results demonstrably influence chemotherapy recommendations by clinicians.
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