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ASCO 2018 NSCLC highlights-combination therapy is key.

Gabriele Gamerith1, Florian Kocher1, Jakob Rudzki1

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ASCO 2018 highlighted immune checkpoint blockade (ICB) and combination therapies as key advances in non-small cell lung cancer (NSCLC) treatment. Biomarker research is evolving, with blood-based tests showing promise for personalized NSCLC therapy.

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Area of Science:

  • Oncology
  • Clinical Trials
  • Cancer Biomarkers

Background:

  • Non-small cell lung cancer (NSCLC) treatment landscape is rapidly evolving.
  • Immune checkpoint blockade (ICB) has emerged as a significant therapeutic strategy.
  • Advances in predictive biomarkers are crucial for optimizing NSCLC treatment.

Purpose of the Study:

  • To summarize key findings and practice-changing potential presented at ASCO 2018 for NSCLC.
  • To highlight the role of ICB and combination therapies in NSCLC treatment.
  • To discuss the advancements in predictive biomarkers for ICB therapy.

Main Methods:

  • Review of presented phase III trials at ASCO 2018 focusing on NSCLC.
  • Analysis of data on immune checkpoint blockade (ICB) and combination therapies.
  • Evaluation of studies on predictive biomarkers, including PD-L1 expression and tumor mutational burden (TMB).

Main Results:

  • ICB confirmed its role in NSCLC without genetic alterations and showed promise in combination therapies, mainly with chemotherapy.
  • Development of predictive biomarkers for ICB, including PD-L1 and TMB, with promising blood-based tests for monitoring.
  • Combinational approaches, such as EGFR TKI plus anti-angiogenic agents or chemotherapy, showed some benefit in genetically altered NSCLC, but toxicity requires further validation.

Conclusions:

  • Combination therapies are poised to become the future standard of care for NSCLC.
  • Biomarker identification for NSCLC treatment is complex, necessitating multimodal approaches.
  • Next-generation techniques offer potential for more personalized cancer therapy in NSCLC.