Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

8.3K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
8.3K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.8K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.8K
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

6.8K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
6.8K
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

4.2K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
4.2K
Bone Structure01:55

Bone Structure

51.7K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.7K
Bone Remodeling01:40

Bone Remodeling

40.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nature's blueprint: Exopolysaccharides linking microbiome dynamics to advanced bone tissue engineering.

Carbohydrate polymers·2026
Same author

3D-Printed Scaffold-Based Glioblastoma Spheroid In Vitro Model for Drug Screening Application.

Annals of biomedical engineering·2025
Same author

Highly tunable coconut shell lignin-gelatin crosslinked hydrogel for controlled drug delivery in wound healing.

International journal of biological macromolecules·2025
Same author

IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation.

Cell reports·2025
Same author

Applying the transfer learning models on the dataset on the effect of diseases on Nagvel-betel (Piper betle) leaves.

Data in brief·2025
Same author

Prospects of injectable hydrogels for bone tissue engineering applications.

Journal of biomaterials science. Polymer edition·2025
Same journal

In-Depth Analysis of AG73-Dental Pulp Cell Interactions Underlying Adhesion and Mineralization: Insights from Alanine Scanning.

Tissue engineering and regenerative medicine·2026
Same journal

Potentiated Maturation of hPSC-Derived Dopaminergic Neurons via Convergent Genetic and Small Molecule Modulation.

Tissue engineering and regenerative medicine·2026
Same journal

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Diabetic β-Cell Apoptosis and Dedifferentiation by Delivering miR-4436.

Tissue engineering and regenerative medicine·2026
Same journal

Intratumoral Injectable Click-Crosslinked Hyaluronic Acid Depot for Sustained Gemcitabine Delivery.

Tissue engineering and regenerative medicine·2026
Same journal

Pressure-Regulated Chondrogenesis of BMSCs: Static Negative Pressure Primes Differentiation through Apoptotic Vesicles.

Tissue engineering and regenerative medicine·2026
Same journal

Differential Wound Healing Potential of Tonsil Parenchymal and Epithelial Mesenchymal Stromal Cell-Derived Exosomes.

Tissue engineering and regenerative medicine·2026
See all related articles

Related Experiment Video

Updated: Jan 31, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

4.1K

Artificial Bone via Bone Tissue Engineering: Current Scenario and Challenges.

Shivaji Kashte1,2, Amit Kumar Jaiswal3, Sachin Kadam2

  • 11Department of Biosciences and Technology, Defence Institute of Advanced Technology, Girinagar, Pune, MS 411025 India.

Tissue Engineering and Regenerative Medicine
|January 4, 2019
PubMed
Summary
This summary is machine-generated.

Bone tissue engineering offers alternatives to traditional bone grafts. This review covers natural and synthetic scaffolds and stem cells for bone repair, discussing their advantages and disadvantages.

Keywords:
BoneBone tissue engineeringGrowth factorsRegenerative medicineScaffolds

More Related Videos

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.7K
Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.1K

Related Experiment Videos

Last Updated: Jan 31, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

4.1K
Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.7K
Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.1K

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • Bone serves crucial structural, metabolic, and protective functions.
  • Repairing bone defects is a significant challenge in orthopedics.
  • Conventional bone grafts have limitations.

Purpose of the Study:

  • To review advancements in bone tissue engineering.
  • To discuss natural and synthetic scaffold materials.
  • To evaluate cellular components like stem cells for bone regeneration.

Main Methods:

  • Literature review of natural and synthetic scaffold materials.
  • Analysis of scaffold properties for bone regeneration.
  • Inclusion of cellular therapies, such as stem cells.

Main Results:

  • Various natural and synthetic materials (metals, ceramics, polymers) are explored.
  • Scaffolds facilitate bone regeneration by providing structural support.
  • Stem cells show potential in enhancing bone formation.

Conclusions:

  • Bone tissue engineering presents promising alternatives to bone grafts.
  • Material selection and cell integration are key for successful bone repair.
  • Further research is needed to optimize scaffold and cell combinations.