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Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

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Prospects of injectable hydrogels for bone tissue engineering applications.

Gajanan Arbade¹, Sayali Chandekar², Nikita Shinde³

¹National Centre for Cell Science, Pune, India.

Journal of Biomaterials Science. Polymer Edition

|August 14, 2025

Summary

Injectable hydrogels offer promising solutions for bone defects. This review highlights their preparation, properties, and applications in bone tissue engineering (BTE), emphasizing their potential for treating critical bone defects.

Keywords:

Biomaterials bone tissue engineering cell encapsulation crosslinking injectable hydrogels

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Last Updated: Sep 11, 2025

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

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The Quantification of Injectability by Mechanical Testing

The Quantification of Injectability by Mechanical Testing

Published on: May 13, 2020

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Bone defects from trauma, fractures, and diseases present a significant clinical challenge.
Biomaterial scaffolds are crucial for tissue engineering (TE) approaches to bone repair.
Injectable hydrogels are emerging as advanced biomaterial scaffolds for bone tissue engineering (BTE).

Purpose of the Study:

To review the preparation, types, properties, and applications of injectable hydrogels.
To emphasize the specific role and potential of injectable hydrogels in bone tissue engineering (BTE).
To discuss the synergistic effects of hydrogels with other biomaterials and cell-encapsulated hydrogels for BTE.

Main Methods:

Literature review focusing on injectable hydrogels in bone tissue engineering.
Analysis of hydrogel properties relevant to bone regeneration.
Discussion of synergistic strategies and cell integration for enhanced BTE.

Main Results:

Injectable hydrogels possess favorable properties for BTE, including high water content, biomimicry, tunable mechanics, and minimal invasiveness.
Hydrogels can effectively conform to irregular bone defects.
Synergistic combinations and cell encapsulation enhance hydrogel performance in BTE.

Conclusions:

Injectable hydrogels represent a highly promising biomaterial for bone tissue engineering.
Their versatility and adaptability make them suitable for addressing critical bone defects.
Further research and implementation of injectable hydrogels are crucial for advancing BTE clinical applications.