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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
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Cellulose-based bioactive material and turmeric-impregnated flexible and biocompatible scaffold for bone tissue
Shital S Shendage1, Kranti Kachare1, Kajal Gaikwad2
1Green Nanotechnology Laboratory, Department of Chemistry, Shivaji University, Kolhapur 416004, India. avg_chem@unishivaji.ac.in.
Journal of Materials Chemistry. B
|February 11, 2025
Summary
Researchers developed a novel bone scaffold using recycled rice husks and eggshells. This eco-friendly material shows excellent biocompatibility and promotes bone regeneration, offering a sustainable alternative for bone tissue engineering.
Area of Science:
- Biomaterials Science
- Materials Engineering
- Regenerative Medicine
Background:
- Current bone defect treatments like metal implants, autografts, and allografts have limitations.
- There's a growing need for cost-effective, eco-friendly, and customizable bone scaffolds with optimal porosity and mechanical properties.
- Utilizing biowaste for scaffold synthesis is crucial for reducing environmental pollution and production costs.
Purpose of the Study:
- To develop a sustainable and bioactive scaffold for bone tissue engineering.
- To utilize recycled rice husk and eggshells for synthesizing a calcium silicate bioactive material (70S30C).
- To impregnate the bioactive material and turmeric powder onto a cellulose-based cotton fabric for enhanced properties.
Main Methods:
- Synthesized 70S30C bioactive material (BM) via precipitation using rice husk and eggshells.
- Impregnated BM and turmeric powder (Tm) onto cellulose fabric (CF).
- Characterized scaffolds using UV-Vis, XRD, FTIR, SEM, EDS; performed in vitro bioactivity, degradation, and hemolysis studies; conducted ex ovo CAM assay and in vivo biocompatibility and osteogenesis assessments.
Main Results:
- Characterization confirmed scaffold properties.
- In vitro studies showed good bioactivity, degradation, and <5% hemolysis (haemocompatibility).
- Ex ovo CAM assay demonstrated neovascularization; in vivo studies confirmed non-toxicity, bone regeneration capacity, and antibacterial properties.
Conclusions:
- The cellulose fabric scaffold impregnated with bioactive material and turmeric is a promising, cost-effective, and eco-friendly option for bone tissue engineering.
- The developed scaffold exhibits desirable porosity, flexibility, bioactivity, degradability, haemocompatibility, osteogenesis, and antibacterial properties.
- This approach offers a sustainable solution for bone defect treatment, leveraging biowaste materials.
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